The response to treatment of subclinical thiamine deficiency in the elderly
| Autor: | H C Hanger, Peter M. George, Jane L. Elmslie, Richard Sainsbury, Tim J Wilkinson |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Visual analogue scale Administration Oral Medicine (miscellaneous) Blood Pressure Placebo chemistry.chemical_compound Double-Blind Method Weight loss Internal medicine medicine Humans Thiamine Aged Subclinical infection Nutrition and Dietetics business.industry Body Weight Thiamine Deficiency food and beverages B vitamins Endocrinology Blood pressure chemistry Quality of Life Female Thiamine Pyrophosphate medicine.symptom business human activities Thiamine pyrophosphate |
| Zdroj: | The American Journal of Clinical Nutrition. 66:925-928 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/66.4.925 |
| Popis: | The significance of subclinical thiamine defi- ciency in the elderly was determined by assessing response to thiamine supplementation in a randomized double-blind, place- bo-controlled trial. Thirty-five of 222 people aged � 65 y had two concentrations of erythrocyte thiamine pyrophosphate (TPP) < 140 nmollL 3 mo apart and 41 other people had the first, but not the second, TPP concentration below this value. Both groups were randomly assigned in a double-blind trial to oral thiamine (10 mg/d) or a placebo. All subjects randomly assigned to receive thiamine showed increases in TPP concen- trations compared with control subjects. Only the subjects with persistently low TPP concentrations showed subjective benefits from treatment with improvements in quality of life (measured on a visual analogue scale; P = 0.02) and decreases in systolic blood pressure (P = 0.05) and weight (P < 0.01) when corn- pared with subjects given placebo. There was a trend toward benefits in sleep and energy (P = 0.07). We conclude that a low TPP concentration on two occasions is a better predictor of response to treatment than an isolated measurement. Quality of life was enhanced by providing thiamine supplements. Blood pressure and weight were lower after thiamine supplementation. Am J Clin Nutr 1997;66:925-8. |
| Databáze: | OpenAIRE |
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