Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice
| Autor: | Thomas Zwakhals, Anne-Emilie Decleves, Olivia Botton, Morgane Decarnoncle, Alexandra Tassin, Florian Juszczak, Maud Vlassembrouck, Nathalie Caron |
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| Rok vydání: | 2020 |
| Předmět: |
Male
AMPK 0301 basic medicine Mice Obese AMP-Activated Protein Kinases 030204 cardiovascular system & hematology medicine.disease_cause lcsh:Chemistry Mice 0302 clinical medicine Fibrosis Chronic kidney disease Phosphorylation lcsh:QH301-705.5 Spectroscopy General Medicine Computer Science Applications High-fat diet cardiovascular system lipids (amino acids peptides and proteins) medicine.symptom medicine.medical_specialty Inflammation Ectopic lipid accumulation Endurance exercise training Diet High-Fat Article Catalysis Inorganic Chemistry 03 medical and health sciences Insulin resistance Endurance training Physical Conditioning Animal Internal medicine Glucose Intolerance Autophagy medicine Animals Obesity Renal Insufficiency Chronic Physical and Theoretical Chemistry Molecular Biology business.industry Organic Chemistry Lipid Metabolism medicine.disease Mice Inbred C57BL 030104 developmental biology Endocrinology lcsh:Biology (General) lcsh:QD1-999 Steatosis business Oxidative stress Kidney disease |
| Zdroj: | Juszczak, F, Vlassembrouck, M, Botton, O, Zwakhals, T, Decarnoncle, M, Tassin, A, Caron, N & Declèves, A E 2021, ' Delayed exercise training improves obesity-induced chronic kidney disease by activating ampk pathway in high-fat diet-fed mice ', International Journal of Molecular Sciences, vol. 22, no. 1, 350, pp. 1-20 . https://doi.org/10.3390/ijms22010350 International Journal of Molecular Sciences Volume 22 Issue 1 International Journal of Molecular Sciences, Vol 22, Iss 350, p 350 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22010350 |
| Popis: | Exercise training is now recognized as an interesting therapeutic strategy in managing obesity and its related disorders. However, there is still a lack of knowledge about its impact on obesity-induced chronic kidney disease (CKD). Here, we investigated the effects of a delayed protocol of endurance exercise training (EET) as well as the underlying mechanism in obese mice presenting CKD. Mice fed a high-fat diet (HFD) or a low-fat diet (LFD) for 12 weeks were subsequently submitted to an 8-weeks EET protocol. Delayed treatment with EET in obese mice prevented body weight gain associated with a reduced calorie intake. EET intervention counteracted obesity-related disorders including glucose intolerance, insulin resistance, dyslipidaemia and hepatic steatosis. Moreover, our data demonstrated for the first time the beneficial effects of EET on obesity-induced CKD as evidenced by an improvement of obesity-related glomerulopathy, tubulo-interstitial fibrosis, inflammation and oxidative stress. EET also prevented renal lipid depositions in the proximal tubule. These results were associated with an improvement of the AMPK pathway by EET in renal tissue. AMPK-mediated phosphorylation of ACC and ULK-1 were particularly enhanced leading to increased fatty acid oxidation and autophagy improvement with EET in obese mice. |
| Databáze: | OpenAIRE |
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