Disappearance of perihepatic lymph node enlargement after hepatitis C viral eradication with direct-acting antivirals
| Autor: | Hiroaki Gotoh, Hiromi Hikita, Masaya Sato, H. Ikeda, Shinji Sone, Kazuhiko Koike, Tamaki Kobayashi, Ryo Nakagomi, Mamiko Sato, Tomomi Iwai, Ryosuke Tateishi, Yutaka Yatomi, Yoko Soroida, Momoe Endo, T. Komuro |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hepatitis C virus Chronic liver disease DIRECT ACTING ANTIVIRALS medicine.disease_cause Antiviral Agents Gastroenterology 03 medical and health sciences 0302 clinical medicine Virology Internal medicine medicine Clinical endpoint Humans Lymph node Aged Hepatology business.industry Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease digestive system diseases Treatment Outcome 030104 developmental biology Infectious Diseases medicine.anatomical_structure Hepatocellular carcinoma Immunology Female 030211 gastroenterology & hepatology Lymph Nodes Lymph business |
| Zdroj: | Journal of Viral Hepatitis. 25:329-334 |
| ISSN: | 1352-0504 |
| DOI: | 10.1111/jvh.12819 |
| Popis: | Perihepatic lymph node enlargement (PLNE) which has been shown to be negatively associated with hepatocellular carcinoma (HCC) occurrence is frequently observed in chronic liver disease, however, changes in the state of perihepatic lymph nodes after eradication of hepatitis C virus (HCV) have not been investigated yet. We aimed to evaluate this issue. We enrolled 472 patients with chronic HCV who achieved viral eradication with direct-acting antivirals (DAA). We investigated whether the status of perihepatic lymph nodes changed before and after HCV eradication (primary endpoint). We also evaluated the association between PLNE and clinical findings such as liver fibrosis or hepatocellular injury before HCV eradication (secondary endpoint). PLNE was detected in 164 of 472 (34.7%) patients before DAA treatment. Surprisingly, disappearance of PLNE was observed in 23.8% (39 patients) of all PLNE positive patients after eradication of HCV. Disappearance of PLNE was not associated with baseline clinical parameters or changing rates of clinical findings before and after DAA treatment. At baseline, presence of PLNE was significantly associated with lower serum HCV-RNA level (P = 0.03), a higher serum AST level (P = 0.004), and a higher ALT level (P |
| Databáze: | OpenAIRE |
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