Immunoglobulin A and liver diseases
| Autor: | Tatsuo Inamine, Bernd Schnabl |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Immunoglobulin A medicine.medical_specialty Alcoholic liver disease Clinical Sciences Review Gut flora digestive system Pathogenesis 03 medical and health sciences Non-alcoholic Fatty Liver Disease NAFLD Internal medicine medicine Humans Liver Diseases Alcoholic Gut microbiome Gastroenterology & Hepatology biology Liver Diseases digestive oral and skin physiology Fatty liver NASH Gastroenterology Hepatology Alcoholic Secretory medicine.disease biology.organism_classification Intestinal epithelium Gastrointestinal Microbiome 3. Good health Intestines 030104 developmental biology ALD Immunoglobulin A Secretory Immunology biology.protein Steatohepatitis IgA |
| Zdroj: | Journal of Gastroenterology Journal of gastroenterology, vol 53, iss 6 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s00535-017-1400-8 |
| Popis: | Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development. The liver is the front-line organ that receives gut-derived products through the portal vein, implying that the liver could be severely affected by a disrupted intestinal homeostasis. Indeed, some liver diseases like alcoholic liver disease are associated with an altered composition of gut microbiota and increased blood endotoxin levels. Therefore, deficiency of SIgA function appears as a significant factor for the pathogenesis of liver diseases associated with altered gut microbiome. In this review, we describe SIgA functions on the gut microbiome and discuss the role of IgA for liver diseases, especially alcoholic liver disease and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. |
| Databáze: | OpenAIRE |
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