Identification of Peptide Oxidation by Tandem Mass Spectrometry

Autor:	Kevin L. Schey, Eric L. Finley
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Chemistry Peptide Oxidation reduction General Medicine General Chemistry Tandem mass spectrometry Mass spectrometry Crystallins Mass Spectrometry Biochemistry Lens Crystalline Animals Humans Cattle Identification (biology) Amino Acids Peptides Oxidation-Reduction
Zdroj:	Accounts of Chemical Research. 33:299-306
ISSN:	1520-4898 0001-4842
Popis:	Oxidative reactions play important roles in a variety of biochemical events ranging from normal metabolism to aging and disease processes. Proteins represent major targets for modification in these reactions, and identification of sites and structures of modifications may lead to mechanistic understanding and approaches for prevention. In this Account, the utility of mass spectrometry and its advantages are described for the identification of oxidative modifications to protein targets. A variety of examples are provided to illustrate how modifications are accurately identified and quantitated using modern methods of ionization coupled with HPLC and tandem mass spectrometry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4554a4ce7678873ab4a4010c87f7775e https://doi.org/10.1021/ar9800744 Zobrazit plný text záznamu