ABC of clinical haematology. The future of haematology, molecular biology, and gene therapy
| Autor: | Sally Ager, Stephen J. Russell, Adele Kay Fielding |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Genetic enhancement Scientific thought Haemophilia Hemophilia A Genetic therapy Internal medicine medicine Humans Intensive care medicine General Environmental Science Hematology Leukemia Molecular pathology business.industry General Engineering Anemia General Medicine Genetic Therapy medicine.disease Hematologic Diseases Clinical Practice Immunology General Earth and Planetary Sciences business Research Article |
| Zdroj: | BMJ (Clinical research ed.). 314(7091) |
| ISSN: | 0959-8138 |
| Popis: | This article will assess the impact of advances in science and technology on the practice of haematology and attempt to predict how haematology will change further over the next 10 to 15 years. #### The future of haematology–diagnosis and treatment ##### Diagnosis ##### Treatment The major advances in scientific thought and technological development that have already changed the practice of modern haematology are likely to affect both laboratory diagnosis and treatment in the future. This article will address three specific area of haematology–anaemia, haemophilia, and leukaemia–and explain how important innovations could be expected to change clinical practice in these areas. The article begins, however, with an overview of gene therapy, which, although currently some way from curing haematological diseases, is likely to have a role in most areas of haematological practice in the future. Both diagnostically and therapeutically, the identification of the molecular pathology of the underlying disorder will continue to steer the future, but the ability to make more accurate diagnoses has not yet resulted in improved treatment. The term gene therapy is applied to any manoeuvre in which genes or genetically modified cells are introduced into a patient for therapeutic benefit. Gene therapy is still in its infancy, and despite the potential of the approach, clinical benefit has yet to be shown. Successful gene therapy depends on the availability of reliable methods for delivering a gene into the nuclei … |
| Databáze: | OpenAIRE |
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