Evaluation of serum transferrin receptor assay in a centralized iron screening service
| Autor: | A. Balfe, C. Mc Mahon, B. Kelleher, S. O'broin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Erythrocyte Indices
Male medicine.medical_specialty Clinical Biochemistry Protoporphyrins Transferrin receptor Sensitivity and Specificity Gastroenterology Diagnosis Differential chemistry.chemical_compound Predictive Value of Tests Internal medicine Receptors Transferrin medicine Humans Prospective Studies Prospective cohort study Soluble transferrin receptor Anemia Iron-Deficiency biology Transferrin saturation business.industry Biochemistry (medical) Zinc protoporphyrin C-reactive protein Hematology General Medicine Iron deficiency medicine.disease Diagnostic Services chemistry Predictive value of tests Ferritins Immunology biology.protein Female business Ireland Biomarkers |
| Zdroj: | Clinical and Laboratory Haematology. 27:190-194 |
| ISSN: | 1365-2257 0141-9854 |
| DOI: | 10.1111/j.1365-2257.2005.00680.x |
| Popis: | This study assesses the impact of permitting unrestricted access to requests for soluble transferrin receptor (sTfR) analysis in screening for iron deficiency (ID). Biochemical data including sTfR, serum ferritin (sFn), transferrin saturation, zinc protoporphyrins (ZPP) and also erythrocyte indices are used to highlight the differences between hospital (H) and general practitioner (GP) patient groups. A significantly higher number of abnormal sFn values (40%) over abnormal sTfR values (25%) occurred in GP patients. This trend was reversed in the H patient group where high sTfR values predominated. Consequently, screening with sFn, exclusively, missed ID (sTfR > 28.1 nmol/l) in 5% of GP patients and in 20% of H patients. Some 40% of H patients had elevated CRP values (CRP > 10 mg/l) indicating inflammatory disease, however, ZPP was more efficient than CRP at screening the validity of normal sFn values in the group. Unrestricted access to sTfR, sFn and ZPP analyses should expedite diagnosis in all patients, particularly H patients, but may be costly. The high specificity (>90%) of the mean cell haemoglobin for ID may be under-utilized diagnostically. |
| Databáze: | OpenAIRE |
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