The potential pharmacological mechanisms of β-hydroxybutyrate for improving cognitive functions

Autor:	Jian-Hong, Wang, Lei, Guo, Su, Wang, Neng-Wei, Yu, Fu-Qiang, Guo
Rok vydání:	2022
Předmět:	Pharmacology Amyloid beta-Peptides Cognition 3-Hydroxybutyric Acid Alzheimer Disease Drug Discovery Humans Acetylation Mitochondria
Zdroj:	Current Opinion in Pharmacology. 62:15-22
ISSN:	1471-4892
DOI:	10.1016/j.coph.2021.10.005
Popis:	β-Hydroxybutyl acid (βOHB), the most prevalent type of ketone in the human body, is involved in the pathogenesis of cognitive disorders, especially Alzheimer's dementia (AD), through a variety of mechanisms, such as enhancing mitochondrial metabolism, regulating signaling molecule, increasing histone acetylation, affecting the metabolism of Aβ and Tau proteins, inhibiting inflammation and lipid metabolism, and regulating intestinal microbes. Based on the above findings, clinical drug development in AD has begun to focus on βOHB.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454d842075b28ebc3f0ac9dd05c35b40 https://doi.org/10.1016/j.coph.2021.10.005 Zobrazit plný text záznamu Full Text from ScienceDirect