Synthesis, electrochemical, optical and biological properties of new carbazole derivatives

Autor:	Slawomir Kula, Krzysztof Z. Łączkowski, Klaudia Seklecka, Przemysław Krawczyk
Rok vydání:	2022
Předmět:	Carbazole Carbazoles Substituent Biological activity Electrochemistry Fluorescence Combinatorial chemistry Atomic and Molecular Physics and Optics Analytical Chemistry chemistry.chemical_compound chemistry Biological property Thiazole Structural motif Instrumentation Spectroscopy Fluorescent Dyes
Zdroj:	Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 267:120497
ISSN:	1386-1425
DOI:	10.1016/j.saa.2021.120497
Popis:	Carbazole skeleton is the key structural motif of many biologically active compounds including synthetic and natural products. Based on the (E)-2-(2-(4-9H-carbazol-9-yl)benzylidene) hydrazinyl)thiazole as skeleton, three novel carbazole dyes were synthesized. The scientific analysis includes the effect of changing the strength of the activating substituents and their exchange for the deactivating substituent on the chemical and biological properties. The presented research showed a significant influence of the CH3, OCH3 and CH2 COOC2H5 groups on the spectral properties of the tested derivatives. Their significant influence is also visible in electrochemical, nonlinear-optic and biological properties. The study also included the analysis of the use of the presented derivatives as potential fluorescent probes for in vivo and in vitro tests. Quantum-chemical calculations complement the conducted experiments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454aa5170b552ad6040a369ec2f967cd https://doi.org/10.1016/j.saa.2021.120497 Zobrazit plný text záznamu Full Text from ScienceDirect