Hypodensities within Hematoma is Time-Dependent and Predicts Outcome after Spontaneous Intracerebral Hemorrhage

Autor:	P N Sylaja, Sankara P. Sarma, Sinchu C Maniangatt, Veena Vedartham, Chinmay Nagesh, Sapna Erat Sreedharan, E R Jayadevan, Praveen Kesav
Rok vydání:	2021
Předmět:	Intracerebral hemorrhage medicine.medical_specialty Hematoma Multivariate analysis business.industry medicine.disease Demographic data body regions Stroke onset Neurology Internal medicine medicine Cardiology Prevalence Humans In patient cardiovascular diseases Neurology (clinical) Symptom onset Spontaneous intracerebral hemorrhage business Tomography X-Ray Computed Biomarkers Cerebral Hemorrhage
Zdroj:	Neurology India. 69(3)
ISSN:	1998-4022
Popis:	Background Non-contrast CT (NCCT) brain imaging biomarkers of hematoma expansion in intracerebral hemorrhage (ICH) has gained relevance in recent times. Though intra-hematoma hypodensities (IHH) can predict hematoma expansion and outcome, it is postulated to be time-dependent. Aim To assess the differential prevalence of IHH in spontaneous ICH over time and assess its predictive valve in early hematoma expansion and functional outcome at 3 months. Material and methods Patients with ICH within 48 h of stroke onset were included. Baseline clinical and demographic data were collected. Baseline NCCT brain was analyzed for hematoma volume, characterization of IHH, with 24-hours follow-up NCCT hematoma volume calculated for identification of hematoma expansion. Poor functional outcome was defined as mRS ≥3. Results Around 92 subjects were included in the study. IHH was found in 40%. Prevalence of IHH was higher in those with baseline NCCT performed within 3 h of symptom onset compared to those beyond 3 h (71% vs 29%, P = 0.002). The hematoma expansion was more common in patients with IHH compared to those without (54% vs 29%; P = 0.02). Multivariate analysis revealed the presence of IHH (rather than pattern or number) to be strongly associated with poor functional outcome at 3 months (OR 3.86; 95% CI: 1.11-13.42, P = 0.03). Conclusion There is a decreasing prevalence of IHH as the time from symptom onset to NCCT increases. Nevertheless, its presence is significantly associated with hematoma expansion and predicted poor short-term functional outcomes in spontaneous ICH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4548b7c2d4f55bcfc58dcf784a5512cc https://pubmed.ncbi.nlm.nih.gov/34169867 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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