Nerve Growth Factor in Neurological and Non-Neurological Diseases: Basic Findings and Emerging Pharmacological Prospectives
| Autor: | Luigi Aloe, Paola Tirassa, Luisa Bracci-Laudiero |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Central Nervous System
medicine.medical_treatment Central nervous system Eye Autoimmune Diseases Central nervous system disease Immune system Stress Physiological Immunopathology Nerve Growth Factor Peripheral Nervous System Drug Discovery medicine Animals Humans Pharmacology business.industry Growth factor medicine.disease Peripheral neuropathy Nerve growth factor medicine.anatomical_structure nervous system Immune System Peripheral nervous system Immunology business Neuroscience |
| Zdroj: | Current pharmaceutical design 7 (2001): 113–123. info:cnr-pdr/source/autori:Aloe L. (1), Tirassa P. (1), Bracci-Laudiero L (1)./titolo:Nerve growth factor in neurological and non-neurological diseases: basic findings and emerging pharmacological prospectives./doi:/rivista:Current pharmaceutical design (Print)/anno:2001/pagina_da:113/pagina_a:123/intervallo_pagine:113–123/volume:7 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612013398383 |
| Popis: | Nerve growth factor (NGF) is known to be essential for the survival of peripheral and brain neurons, and according to more recent studies also for a variety of cells localized in the immune system. Basic and preclinical findings published in the last 15-20 years have prospected the hypothesis that NGF can be pharmaceutically useful for promoting healing in certain peripheral and central neurological insults. We have recently provided evidence that NGF applied topically, has a therapeutic potentiality for human corneal and pressure ulcers, and more recently in vasculitis induced by rheumatoid arthritis. This review will summarize previous and ongoing evidence supporting the role of NGF in the nervous and immune system and discuss NGF potentiality as a pharmacological tool for basic and clinical studies. |
| Databáze: | OpenAIRE |
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