Relation of HLA class I and II supertypes with spontaneous clearance of hepatitis C virus
| Autor: | Darlene Marti, Mary Carrington, Alessandro Sette, Ruth M. Greenblatt, Xiao Nan Xue, Chloe L. Thio, Andrea Kovacs, Stephen J. Gange, Howard Minkoff, K. Anastos, Marion G. Peters, Mark H. Kuniholm, Howard D. Strickler, Mary Young, Mardge Cohen, Xiaojiang Gao |
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| Rok vydání: | 2012 |
| Předmět: |
Hla class ii
hepatitis C virus Hepatitis C virus Immunology Population Human leukocyte antigen Hepacivirus Biology medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine HLA Antigens human leukocyte antigen Genotype Genetics medicine Humans Allele Prevalence ratio education Genetics (clinical) 030304 developmental biology HLA-DR Serological Subtypes 0303 health sciences education.field_of_study Hcv clearance supertype Virology Hepatitis C 3. Good health HLA Review Literature as Topic HLA-B Antigens Multivariate Analysis Female 030215 immunology HLA-DRB1 Chains |
| Zdroj: | Genes and immunity |
| ISSN: | 1476-5470 |
| Popis: | Human leukocyte antigen (HLA) genotype has been associated with the probability of spontaneous clearance of hepatitis C virus (HCV). However, no prior studies have examined whether this relationship may be further characterized by grouping HLA alleles according to their supertypes, defined by their binding capacities. There is debate regarding the most appropriate method to define supertypes. Therefore, previously reported HLA supertypes (46 class I and 25 class II) were assessed for their relation with HCV clearance in a population of 758 HCV-seropositive women. Two HLA class II supertypes were significant in multivariable models that included: (i) supertypes with significant or borderline associations with HCV clearance after adjustment for multiple tests, and (ii) individual HLA alleles not part of these supertypes, but associated with HCV clearance in our prior study in this population. Specifically, supertype DRB3 (prevalence ratio (PR)=0.4; P=0.004) was associated with HCV persistence, whereas DR8 (PR=1.8; P=0.01) was associated with HCV clearance. Two individual alleles (B*57:01 and C*01:02) associated with HCV clearance in our prior study became nonsignificant in analysis that included supertypes, whereas B*57:03 (PR=1.9; P=0.008) and DRB1*07:01 (PR=1.7; P=0.005) retained their significance. These data provide epidemiologic support for the significance of HLA supertypes in relation to HCV clearance. |
| Databáze: | OpenAIRE |
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