Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review
| Autor: | Octavio Canales-Álvarez, Gustavo Gorgua-Jiménez, Pilar Dominguez-Verano, Maria Margarita Canales-Martinez, Daniela Balderas-Cordero, M. A. Rodriguez-Monroy, Porfirio Alonso Ruiz-Hurtado, Leticia Garduño-Siciliano |
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| Rok vydání: | 2021 |
| Předmět: |
Future studies
Apitherapy NSAIDs Review phenolic compounds Antioxidants Gastric mucosa medicine Animals Humans TX341-641 Stomach Ulcer Adverse effect GASTRIC ULCER DISEASE Nutrition and Dietetics Traditional medicine Nutrition. Foods and food supply business.industry Anti-Inflammatory Agents Non-Steroidal Propolis Anti-Ulcer Agents gastric ulcer disease digestive system diseases propolis Treatment Outcome medicine.anatomical_structure Gastric Mucosa business Food Science Systematic search |
| Zdroj: | Nutrients, Vol 13, Iss 3169, p 3169 (2021) Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13093169 |
| Popis: | Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people. |
| Databáze: | OpenAIRE |
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