Body fat and RNA content of the VMH cells in rats neonatally treated with monosodium glutamate
| Autor: | Mozes S, Kuchár S, Wei Min Zhang |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Fat content Monosodium glutamate Injections Subcutaneous Hypothalamus Adipose tissue Significant negative correlation Biology chemistry.chemical_compound Internal medicine Sodium Glutamate medicine Animals Rats Wistar Neurons General Neuroscience Body Weight RNA Cortical neurons medicine.disease Obesity Rats Endocrinology chemistry Adipose Tissue Animals Newborn Female Densitometry |
| Zdroj: | Brain research bulletin. 35(4) |
| ISSN: | 0361-9230 |
| Popis: | The RNA content of the ventromedial hypothalamus (VMH), the lateral hypothalamic area (LHA), and the cortical neurons of male and female rats, neonatally treated with monosodium glutamate (MSG), were investigated. MSG (2 g/kg b.wt.) was injected subcutaneously to male and female rat pups daily for 5 days after birth. At 12 weeks of age a significant decrease of RNA content in the VMH cells and significantly increased body fat in neonatally MSG-treated animals were found. Correlation of these data showed a significant negative correlation between the body fat content and the RNA content in VMH neurons. The results a) confirm a closed relationship between the body fat content and the functional activity of VMH, b) indicate that obesity of neonatally MSG-treated animals should be due to decreased functional activity of the VMH cells. |
| Databáze: | OpenAIRE |
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