An Immunological Evaluation of Type II Diabetic Patients with Periodontal Disease
| Autor: | F. Fusetti, S. De Toni, Annunziata Lapolla, Michele Mussap, M. Sanzari, Mario Plebani, David A. Fedele, G. Fontana, Elisa Piva |
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| Rok vydání: | 1999 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Lymphocyte Alveolar Bone Loss Dental Plaque Tooth Loss Endocrinology Immune system Antigens CD T-Lymphocyte Subsets Diabetes mellitus Internal medicine Internal Medicine medicine Tooth loss Humans Periodontal Diseases Dental alveolus Respiratory Burst Immunity Cellular biology business.industry NADPH Oxidases Complement System Proteins Middle Aged medicine.disease Pathophysiology Immunoglobulin A medicine.anatomical_structure Diabetes Mellitus Type 2 Immunoglobulin M Immunoglobulin G Antibody Formation Gingival Diseases biology.protein Female Antibody medicine.symptom business Complication |
| Zdroj: | Journal of Diabetes and its Complications. 13:23-30 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/s1056-8727(98)00021-x |
| Popis: | Peridontal disease is a frequent complication of diabetes, and diabetic subjects often exhibit decreased immune response with increased susceptibility to infection. We evaluated the possible relationship between immune response and periodontal disease in 40 type II diabetic patients, mean (+/- SD) age 59 +/- 8 years and mean disease duration 17 +/- 4 years, with good metabolic control (mean fasting plasma glucose, 10.5 +/- 3.8 mM/L, mean HbA1c 8.1 +/- 1.66%), and in 40 age and gender-matched controls. Interproximal alveolar bone loss (ABL), as the percentage of bone loss from the cement enamel junction (CEJ) to the apex, was measured with a modified Schei ruler at the deepest point on the mesial/distal surface of the teeth, except third molars, on a panoramic radiograph. Immunological evaluation involved study of NADPH neutrophil superoxide production, neutrophil chemotaxis, lymphocyte subpopulations, immunoglobulins and complement. Diabetic patients showed significant differences compared with controls regarding ABL (30.6 +/- 14.7% versus 17.6 +/- 4.3%; p < 0.0001) and the T-helper/T-suppressor ratio (2.3 +/- 1.0% versus 1.8 +/- 0.8%; p < 0.05). Other parameters of cell-mediated immunity and humoral immune response did not show any significant variations. No correlation between immunological and radiographic analysis parameters were found. Further studies are needed to verify the exact role played by immunological factors in type II diabetic patients with periodontal disease. |
| Databáze: | OpenAIRE |
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