A retrospective analysis of adverse effects of an in vivo fluoroquinolone antibiotic enrofloxacin treatment on oocyte quality in the common marmoset
| Autor: | Michael Heistermann, S. Delimitreva, Olena Y. Tkachenko, P.L. Nayudu, R.R. Valle, Edris Wedi, J.U. Scheerer-Bernhard |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Ovariectomy Administration Oral Spindle Apparatus Toxicology Andrology 03 medical and health sciences Human fertilization In vivo biology.animal Enrofloxacin medicine Animals Cumulus Cells biology Marmoset Embryo Callithrix Estrogens Oocyte 3. Good health Anti-Bacterial Agents 030104 developmental biology medicine.anatomical_structure Fertilization Toxicity Oocytes Female Reproductive toxicity medicine.drug Fluoroquinolones |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 75 |
| ISSN: | 1873-1708 |
| Popis: | Here we report a retrospective analysis of negative effects of routine enrofloxacin treatment of recurrent diarrhea on the ovary and the developing oocytes of the common marmoset, a small New World primate. The most deleterious effect on oocytes was observed about two months post treatment suggesting that the enrofloxacin effect is on early growing follicles. Manifestations of toxicity included decreased numbers of growing follicles and recovered culturable oocytes, as well as signs of early atresia of granulosa cells. In addition, increased amounts of holed stroma after treatment strongly suggested increased death of the early growing follicles. Of the oocytes judged to be of adequate quality for culture, maturation rates were not affected but fertilization of in vitro matured MII oocytes and subsequent cleavage rates were severely reduced in the enrofloxacin treated animals. Further, the arrested oocytes, which failed to mature or fertilize, showed obvious meiotic spindle abnormalities. |
| Databáze: | OpenAIRE |
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