Acute hepatitis B caused by a vaccine-escape HBV strain in vaccinated subject: sequence analysis and therapeutic strategy
| Autor: | Veronica Bernabucci, Stefano Gitto, Rosina Maria Critelli, Erica Villa, Mirco Bevini, Giuliano Montagnani, Monica Luongo, Chiara Vecchi, Antonella Grottola |
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| Rok vydání: | 2014 |
| Předmět: |
Male
HBsAg Hepatitis B virus Genotype Acute hepatitis Escape mutant Telbivudine Vaccine Molecular Sequence Data Viremia Biology medicine.disease_cause Virology medicine Humans Hepatitis B Vaccines Amino Acid Sequence Hepatitis B immune globulin Hepatitis B Surface Antigens Vaccination virus diseases Middle Aged medicine.disease Hepatitis B digestive system diseases Infectious Diseases HBeAg Immunology Mutation biology.protein Antibody Vaccine failure Sequence Alignment medicine.drug |
| Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 62 |
| ISSN: | 1873-5967 |
| Popis: | HBV vaccine contains the ‘a’ determinant region, the major immune-target of antibodies (anti-HBs). Failure of immunization may be caused by vaccine-induced or spontaneous ‘a’ determinant surface gene mutants. Here, we evaluate the possible lack of protection by HBV vaccine, describing the case of an acute hepatitis B diagnosed in a 55-year-old Caucasian male unpaid blood donor, vaccinated against HBV. Sequencing data for preS–S region revealed multiple point mutations. Of all the substitutions found, Q129H, located in the “a” determinant region of HBsAg, can alter antigenicity, leading to mutants. This mutant may cause vaccine failure especially when associated with high viremia of infecting source. |
| Databáze: | OpenAIRE |
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