A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish
| Autor: | Kayla Kindig, Jiaqi Hu, Carol A. Fernando, Zongwei Chen, William Brown, Ruben Stepanyan, Brian M. McDermott, Robin Woods Davis, Shaoyuan Zhu, Shih Wei Chou, Li Liu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Water flow Science Stereocilia (inner ear) Lateral line General Physics and Astronomy Sensory system Mechanotransduction Cellular General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Motion medicine otorhinolaryngologic diseases Animals Mechanotransduction lcsh:Science Zebrafish Multidisciplinary biology integumentary system Chemistry Membrane Proteins Water General Chemistry Zebrafish Proteins biology.organism_classification Lateral Line System 030104 developmental biology medicine.anatomical_structure Biophysics Mechanosensitive channels lcsh:Q Hair cell sense organs Mechanoreceptors |
| Zdroj: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| ISSN: | 2041-1723 |
| Popis: | Detection of water motion by the lateral line relies on mechanotransduction complexes at stereocilia tips. This sensory system is comprised of neuromasts, patches of hair cells with stereociliary bundles arranged with morphological mirror symmetry that are mechanically responsive to two opposing directions. Here, we find that transmembrane channel-like 2b (Tmc2b) is differentially required for mechanotransduction in the zebrafish lateral line. Despite similarities in neuromast hair cell morphology, three classes of these cells can be distinguished by their Tmc2b reliance. We map mechanosensitivity along the lateral line using imaging and electrophysiology to determine that a hair cell’s Tmc2b dependence is governed by neuromast topological position and hair bundle orientation. Overall, water flow is detected by molecular machinery that can vary between hair cells of different neuromasts. Moreover, hair cells within the same neuromast can break morphologic symmetry of the sensory organ at the stereocilia tips. In fish, water motion is detected by mechanosensitive hair cells located in the lateral line. Here the authors show that the molecular machinery for mechanotransduction, including transmembrane channel-like 2b (Tmc2b), varies depending on both hair cell location and hair bundle orientation. |
| Databáze: | OpenAIRE |
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