Higher circulating bile acid concentrations in obese patients with type 2 diabetes
| Autor: | Torsten Olbers, Malin Werling, Roy Sherwood, Jamshid Alaghband-Zadeh, Carel W. le Roux, Royce P Vincent, David R Taylor, Sohail Omar, Gemma F. Cross, Lars Fändriks, Samer Ghozlan |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male Taurine medicine.medical_specialty medicine.drug_class Clinical Biochemistry Incretin Type 2 diabetes Biology Bile Acids and Salts chemistry.chemical_compound Internal medicine medicine Humans Obesity Meal Bile acid Type 2 Diabetes Mellitus Fasting General Medicine Middle Aged Postprandial Period medicine.disease Glucagon-like peptide-1 Up-Regulation Cross-Sectional Studies Endocrinology Diabetes Mellitus Type 2 chemistry Female Biomarkers Hormone |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 50:360-364 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/0004563212473450 |
| Popis: | Background Bile acids (BAs) play an important role in releasing incretin hormones via the enteroendocrine L-cell surface TGR5 receptors. The aim of this study was to investigate the difference in BA concentration at baseline and in response to a meal stimulus between type 2 diabetes mellitus (T2DM) and a matched normoglycaemic group. Materials and methods A cross-sectional study of 12 patients with known T2DM and 12 matched normoglycaemic controls compared BA fractions after an overnight fast and following a standard meal. Results The T2DM group had higher baseline glucose (P Conclusion The post-prandial bile acid response is elevated in obese patients with T2DM compared to matched normoglycaemic individuals. |
| Databáze: | OpenAIRE |
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