The risk of recurrent venous thromboembolism among patients with high factor IX levels
| Autor: | Mirko Hirschl, Peter Quehenberger, V. Schönauer, Christine Bialonczyk, Sabine Eichinger, A. Weltermann, Paul A. Kyrle, Erich Minar |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Hyperhomocysteinemia Deep vein Gastroenterology Factor IX Recurrence Risk Factors Thromboembolism Internal medicine medicine Humans Prospective Studies Risk factor Aged Venous Thrombosis Lupus anticoagulant Factor VIII business.industry Incidence Anticoagulants Hematology Middle Aged medicine.disease Thrombosis Surgery Venous thrombosis medicine.anatomical_structure Relative risk Female business medicine.drug |
| Zdroj: | Journal of Thrombosis and Haemostasis. 1:28-32 |
| ISSN: | 1538-7836 |
| DOI: | 10.1046/j.1538-7836.2003.00038.x |
| Popis: | Summary. High factor IX (FIX) is a risk factor of deep vein thrombosis. The impact of high FIX on the risk of recurrent venous thrombosis is unknown. We prospectively followed 546 patients after anticoagulation for a first spontaneous venous thromboembolism. Patients with a natural coagulation inhibitor deficiency, lupus anticoagulant or cancer were excluded. At 3 years, the likelihood of recurrence was 23% among patients with high FIX (exceeding the 75th percentile) compared with 11% among patients with lower levels. Among patients with high FIX, the relative risk of recurrence was 2.2 (95% CI: 1.3–3.6) before and was 1.6 (95% CI: 1.0–2.8) after adjustment for age, gender, duration of anticoagulation, FV Leiden, FII G20210A, high FVIII and hyperhomocysteinemia. Compared with patients with low factor IX ( |
| Databáze: | OpenAIRE |
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