Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread

Autor: Sanjib Bhattacharyya, William M. Rehrauer, David Baker, Yoshihiro Kawaoka, Mitchell D. Ramuta, Molly A. Accola, Trent M. Prall, John J. Baczenas, Manjeet Khubbar, Michael A. Martin, Caitlin S. Pepperell, Peter Halfmann, Kasen K. Riemersma, Katarina M. Braun, Anna S. Heffron, Katia Koelle, Shelby L. O’Connor, Nasia Safdar, Thomas C. Friedrich, Andrea M. Weiler, David H. O’Connor, Gage K. Moreno, Chelsea M. Crooks, Trivikram Dasu
Rok vydání: 2020
Předmět:
0301 basic medicine
Epidemiology
viruses
General Physics and Astronomy
law.invention
0302 clinical medicine
law
Pandemic
Mass Screening
030212 general & internal medicine
Respiratory Protective Devices
lcsh:Science
skin and connective tissue diseases
Socioeconomics
Molecular Epidemiology
Multidisciplinary
Geography
Viral Epidemiology
Phylogenetics
Transmission (mechanics)
Psychological Distance
Scale (social sciences)
Coronavirus Infections
medicine.medical_specialty
Science
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
Genome
Viral
Article
General Biochemistry
Genetics and Molecular Biology
Betacoronavirus
03 medical and health sciences
Wisconsin
medicine
Humans
Pandemics
Mass screening
SARS-CoV-2
Public health
fungi
COVID-19
Outbreak
General Chemistry
United States
body regions
030104 developmental biology
Viral infection
lcsh:Q
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
medRxiv
article-version (status) pre
article-version (number) 1
ISSN: 2041-1723
Popis: Evidence-based public health approaches that minimize the introduction and spread of new SARS-CoV-2 transmission clusters are urgently needed in the United States and other countries struggling with expanding epidemics. Here we analyze 247 full-genome SARS-CoV-2 sequences from two nearby communities in Wisconsin, USA, and find surprisingly distinct patterns of viral spread. Dane County had the 12th known introduction of SARS-CoV-2 in the United States, but this did not lead to descendant community spread. Instead, the Dane County outbreak was seeded by multiple later introductions, followed by limited community spread. In contrast, relatively few introductions in Milwaukee County led to extensive community spread. We present evidence for reduced viral spread in both counties following the statewide “Safer at Home” order, which went into effect 25 March 2020. Our results suggest patterns of SARS-CoV-2 transmission may vary substantially even in nearby communities. Understanding these local patterns will enable better targeting of public health interventions.
In this study, the authors present an analysis of 247 full-genome SARS-CoV-2 sequences obtained from two communities in Wisconsin, USA, and report distinct patterns of viral spread. Their results suggest that patterns of SARS-CoV-2 transmission and spread may vary substantially, even between neighbouring communities.
Databáze: OpenAIRE
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