Racial and Ethnic Differences in Breast Cancer Survival: Mediating Effect of Tumor Characteristics and Sociodemographic and Treatment Factors
Autor: | Douglas W. Blayney, Jane C. Weeks, Richard L. Theriault, Rebecca A. Ottesen, Y. Wong, Ann H. Partridge, Erica T. Warner, Melissa E. Hughes, Eric P. Winer, Joyce C. Niland, Rulla M. Tamimi, Stephen B. Edge |
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Rok vydání: | 2015 |
Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Multivariate analysis Time Factors Breast Neoplasms Triple Negative Breast Neoplasms Disease-Free Survival White People Body Mass Index Breast cancer Risk Factors Internal medicine Cause of Death Biomarkers Tumor Ethnicity Medicine Humans Healthcare Disparities Cause of death Aged Neoplasm Staging Proportional Hazards Models Gynecology Asian business.industry Proportional hazards model Hazard ratio Racial Groups Cancer Health Status Disparities Hispanic or Latino ORIGINAL REPORTS Middle Aged medicine.disease United States Black or African American Logistic Models Treatment Outcome Socioeconomic Factors Multivariate Analysis Female Neoplasm Grading business Body mass index |
Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(20) |
ISSN: | 1527-7755 |
Popis: | Purpose To evaluate the relationship between race/ethnicity and breast cancer–specific survival according to subtype and explore mediating factors. Patients and Methods Participants were women presenting with stage I to III breast cancer between January 2000 and December 2007 at National Comprehensive Cancer Network centers with survival follow-up through December 2009. Cox proportional hazards regression was used to compare breast cancer–specific survival among Asians (n = 533), Hispanics (n = 1,122), and blacks (n = 1,345) with that among whites (n = 14,268), overall and stratified by subtype (luminal A like, luminal B like, human epidermal growth factor receptor 2 type, and triple negative). Model estimates were used to derive mediation proportion and 95% CI for selected risk factors. Results In multivariable adjusted models, overall, blacks had 21% higher risk of breast cancer–specific death (hazard ratio [HR], 1.21; 95% CI, 1.00 to 1.45). For estrogen receptor–positive tumors, black and white survival differences were greatest within 2 years of diagnosis (years 0 to 2: HR, 2.65; 95% CI, 1.34 to 5.24; year 2 to end of follow-up: HR, 1.50; 95% CI, 1.12 to 2.00). Blacks were 76% and 56% more likely to die as a result of luminal A–like and luminal B–like tumors, respectively. No disparities were observed for triple-negative or human epidermal growth factor receptor 2–type tumors. Asians and Hispanics were less likely to die as a result of breast cancer compared with whites (Asians: HR, 0.56; 95% CI, 0.37 to 0.85; Hispanics: HR, 0.74; 95% CI, 0.58 to 0.95). For blacks, tumor characteristics and stage at diagnosis were significant disparity mediators. Body mass index was an important mediator for blacks and Asians. Conclusion Racial disparities in breast cancer survival vary by tumor subtype. Interventions are needed to reduce disparities, particularly in the first 2 years after diagnosis among black women with estrogen receptor–positive tumors. |
Databáze: | OpenAIRE |
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