Author Correction: Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
| Autor: | Marianna Meschiari, Carlene Petes, Cristina Mussini, Sara De Biasi, Jordan Nieto, Francesco M. Galassi, Geneve Awong, Andrew A. Quong, Dongxia Lin, Luca Cicchetti, Fabio Facchinetti, Tommaso Trenti, Lucia Fidanza, Domenico Lo Tartaro, Mario Sarti, Rebecca Borella, Samuel Douglas, Anna Iannone, Chiara Leone, Marco Mattioli, Lara Gibellini, Annamaria Paolini, Giovanni Guaraldi, Isabella Neri, Andrea Cossarizza, Massimo Girardis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Adolescent Neutrophils Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science General Physics and Astronomy Translational immunology Inflammation Endogeny Viral infection Asymptomatic General Biochemistry Genetics and Molecular Biology Young Adult Pregnancy Medicine Humans Pregnancy Complications Infectious Author Correction Asymptomatic Infections Multidisciplinary business.industry SARS-CoV-2 COVID-19 General Chemistry Middle Aged Virology Cross-Sectional Studies Case-Control Studies Cytokines Female medicine.symptom business Biomarkers |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink