| Autor: |
Paul Rene De Cotret, Maurice Soowamber, Patrick Vinay, André Gougoux |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
American Journal of Kidney Diseases. 14:285-288 |
| ISSN: |
0272-6386 |
| DOI: |
10.1016/s0272-6386(89)80204-5 |
| Popis: |
The total body clearance of glutamine in five normal and four acidotic dogs was estimated from the kinetics of disappearance from the blood of 14 C-[U]-L-glutamine administered in a central vein as a single bolus. The disappearance curve was analyzed as reflecting a biexponential phenomenon with both a mixing and a metabolism component occurring, respectively, in the extracellular (mixing) and intracellular compartment (metabolism). The apparent total body metabolism of glutamine (total body clearance x arterial concentration) was compared with the renal use of this aminoacid as directly determined by renal A-V differences and blood flow. It was demon strated that the renal use of glutamine represents between 13% and 25% of the total body use, and was increased by acidosis, which did not change significantly the overall rate of synthesis or use. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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