Abnormal neural hierarchy in processing of verbal information in patients with schizophrenia
| Autor: | Ilana Kremer, Waheed Madah, Talma Hendler, Shimrit Solnik-Knirsh, Maya Bleich-Cohen, Alon Shamir, Tamir Eisenstein, Galit Yogev-Seligmann, Yulia Lerner |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Neuropsychological Tests Audiology Functional Laterality lcsh:RC346-429 Random Allocation Cognition Mental Processes 0302 clinical medicine Information processing Neural Pathways Image Processing Computer-Assisted media_common Brain Mapping medicine.diagnostic_test fMRI Brain Regular Article Middle Aged Magnetic Resonance Imaging Neurology lcsh:R858-859.7 Female Psychology Antipsychotic Agents Adult medicine.medical_specialty Narrated story Cognitive Neuroscience media_common.quotation_subject Schizophrenia (object-oriented programming) Sensory system lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities Young Adult 03 medical and health sciences Perception medicine Humans Radiology Nuclear Medicine and imaging Set (psychology) lcsh:Neurology. Diseases of the nervous system Verbal Behavior Siblings 030227 psychiatry Oxygen Comprehension Acoustic Stimulation Schizophrenia Neurology (clinical) Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 17, Iss, Pp 1047-1060 (2018) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2017.12.030 |
| Popis: | Previous research indicates abnormal comprehension of verbal information in patients with schizophrenia. Yet the neural mechanism underlying the breakdown of verbal information processing in schizophrenia is poorly understood. Imaging studies in healthy populations have shown a network of brain areas involved in hierarchical processing of verbal information over time. Here, we identified critical aspects of this hierarchy, examining patients with schizophrenia. Using functional magnetic resonance imaging, we examined various levels of information comprehension elicited by naturally presented verbal stimuli; from a set of randomly shuffled words to an intact story. Specifically, patients with first episode schizophrenia (N = 15), their non-manifesting siblings (N = 14) and healthy controls (N = 15) listened to a narrated story and randomly scrambled versions of it. To quantify the degree of dissimilarity between the groups, we adopted an inter-subject correlation (inter-SC) approach, which estimates differences in synchronization of neural responses within and between groups. The temporal topography found in healthy and siblings groups were consistent with our previous findings – high synchronization in responses from early sensory toward high order perceptual and cognitive areas. In patients with schizophrenia, stimuli with short and intermediate temporal scales evoked a typical pattern of reliable responses, whereas story condition (long temporal scale) revealed robust and widespread disruption of the inter-SCs. In addition, the more similar the neural activity of patients with schizophrenia was to the average response in the healthy group, the less severe the positive symptoms of the patients. Our findings suggest that system-level neural indication of abnormal verbal information processing in schizophrenia reflects disease manifestations. Highlights • Critical aspects in semantic information processing in patients with schizophrenia, their non-manifesting siblings and healthy controls • High synchronization in responses in early sensory areas in all groups • Robust disruption of the responses in high order perceptual and cognitive areas in patients with schizophrenia |
| Databáze: | OpenAIRE |
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