The development and validation of sensitive LC-MS/MS method for quantitative bioanalysis of carmofur in mouse plasma and its application to pharmacokinetic study

Autor:	Mohammad Mohiminul Islam, Ethan F. Kub, Vilashini Rajaratnam, Shama P. Mirza
Rok vydání:	2022
Předmět:	Mice Tandem Mass Spectrometry SARS-CoV-2 Clinical Biochemistry Animals COVID-19 Reproducibility of Results Cell Biology General Medicine Biochemistry Analytical Chemistry Chromatography Liquid
Zdroj:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1212
ISSN:	1873-376X
Popis:	Carmofur is an acid ceramidase inhibitor with superior efficacy in suppressing and killing fatally aggressive glioblastoma cell lines compared to the FDA-approved drug temozolomide. In addition to brain tumors, carmofur also gained attention as a potential lead inhibitor of the main protease (M
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45373cdfb55fa4b8c15b5c39654b9376 https://pubmed.ncbi.nlm.nih.gov/36332509 Zobrazit plný text záznamu Full Text from ScienceDirect