Serum calcitonin may be a marker for inhalation injury in burns
| Autor: | M. H. Jordan, William J. O'Neill, Mark S. Lewis, Kenneth L. Becker, C. F. Moore, Richard H. Snider |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_treatment Radioimmunoassay Blood Urea Nitrogen Phosphates parasitic diseases medicine Humans Prospective Studies Prospective cohort study Lung General Nursing Serum Albumin Mechanical ventilation Inhalation business.industry Rehabilitation Respiratory disease medicine.disease Neurosecretory Systems Anesthesia Inhalation injury Creatinine General Health Professions Emergency Medicine Surgery Calcium Female Complication business Serum calcitonin Biomarkers Burns Inhalation |
| Zdroj: | The Journal of burn carerehabilitation. 13(6) |
| ISSN: | 0273-8481 |
| Popis: | One of the principal causes of death from burns is inhalation injury. The pulmonary neuroendocrine cell contains and secretes immunoreactive calcitonin (iCT), and, under the influence of various irritative stimuli, can be induced to secrete iCT in excess. A prospective study of serum iCT levels in 41 patients with burns was undertaken. Mean serum iCT levels were four times normal values at the time of admission and reached 31 times normal values by 24 hours after injury. These levels did not correlate specifically with burn size. However, serum iCT had a very strong positive correlation with mortality, and in addition, was highest in patients who died early after injury compared with those who died late after injury. Patients who were clinically suspected to have pulmonary injury and who died had markedly higher levels of iCT than those who survived. In addition, serum iCT correlated positively with the need for mechanical ventilation and the amount of pulmonary shunting. Although other factors may also play a role in hypercalcitoninemia, serum iCT may be an important marker for the presence of inhalation injury, as well as a prognostic indicator. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|