Mechanisms of Aβ Clearance and Catabolism
| Autor: | Suzanne Y. Guénette |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genetically modified mouse
Proteases medicine.medical_specialty Neurology Amyloid beta BACE1-AS Disease Mice Cellular and Molecular Neuroscience Alzheimer Disease Internal medicine Endopeptidases medicine Animals Humans Genetic Predisposition to Disease Mice Knockout Amyloid beta-Peptides biology Catabolism P3 peptide Brain Endocrinology biology.protein Molecular Medicine |
| Zdroj: | NeuroMolecular Medicine. 4:147-160 |
| ISSN: | 1535-1084 |
| Popis: | Mutations that result in an increased generation of amyloid beta peptide (Abeta) account for less than 5% of Alzheimer's disease (AD). Data suggesting that late onset AD risk factors play a role in Abeta turnover in the brain have shifted some of the research focus to the study of Abeta clearance and degradation and the impact of these processes on the etiology of Alzheimer's disease (AD). This review will examine the data obtained from studies performed in knockout and transgenic mice on the proteases; the cells and the physiological mechanisms that play a part in the removal of Abeta from the brain. |
| Databáze: | OpenAIRE |
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