Investigating the relationship between fetal growth and academic attainment: secondary analysis of the Born in Bradford (BiB) cohort
| Autor: | Philip N. Baker, Noel Cameron, Samantha Johnson, Emily S. Petherick, Tom Norris, Sam Oddie, Elizabeth S Draper, John Wright, William Johnson |
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| Rok vydání: | 2018 |
| Předmět: |
Male
longitudinal Epidemiology Pregnancy Trimester Third Birth weight Fetal growth Logistic regression Ultrasonography Prenatal Cognitive and Behavioural Outcomes Fetal Development 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Birth Weight Humans Longitudinal Studies 030212 general & internal medicine Child education Academic Success Fetal Growth Retardation Confounding Infant Newborn attainment Secondary data General Medicine spline Random effects model United Kingdom Educational attainment Logistic Models Born in Bradford Cohort Linear Models Female Cohort study Demography |
| Zdroj: | International Journal of Epidemiology |
| ISSN: | 1464-3685 0300-5771 |
| DOI: | 10.1093/ije/dyy157 |
| Popis: | Background The relationship between ultrasongraphically derived estimates of fetal growth and educational attainment in the postnatal period is unknown. Results from previous studies focusing on cognitive ability, however, suggest there may be gestation-specific associations. Our objective was to model growth in fetal weight (EFW) and head circumference (HC) and identify whether growth variation in different periods was related to academic attainment in middle childhood. Methods Data come from the Born in Bradford (BiB) cohort study, which has performed data linkage to both routine antenatal scans and national academic attainment tests at age 6–7 years. Multilevel linear spline models were used to model EFW and HC. Random effects from these were related to Key Stage 1 (KS1) results in reading, writing, mathematics, science and a composite of all four (age 6–7 years), using ordinal logistic and logistic regression. Associations were adjusted for potential confounders, facilitated by directed acyclic graphs. Missing covariate data were imputed using multiple imputation. Results In all, 6995 and 8438 children had complete KS1, and EFW and HC data, respectively. Positive associations were observed between both fetal weight in early pregnancy (14 weeks) and EFW growth in mid-pregnancy (14-26 weeks) and the individual KS1 outcomes. Furthermore, after adjustment for previous size and confounders, a 1-z score increase in growth in mid-pregnancy was associated with an 8% increased odds of achieving the expected standard for all KS1 outcomes [odds ratio (OR): 1.08, 95% confidence interval (CI): 1.02; 1.13]. Similar results were observed for HC, with generally larger effect sizes. Smaller associations were observed with growth in the early-third trimester, with no associations observed with growth in the later-third trimester. Conclusions We observed consistent positive associations between fetal size and growth in early and mid-gestation and academic attainment in childhood. The smaller and null associations with growth in the early-third and later-third trimester, respectively, suggests that early-mid gestation may be a sensitive period for future cognitive development. |
| Databáze: | OpenAIRE |
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