Imbalanced spontaneous brain activity in orbitofrontal-insular circuits in individuals with cognitive vulnerability to depression
| Autor: | Hengyi Rao, Xiaocui Zhang, Hui Lei, Xiang Wang, Xin Di, Shuqiao Yao, Jing Xiao, Juan Yang |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Longitudinal study Adolescent Prefrontal Cortex Neuroimaging Audiology Insular cortex behavioral disciplines and activities Young Adult 03 medical and health sciences Cognition 0302 clinical medicine medicine Humans Psychiatry Prefrontal cortex Cerebral Cortex Depressive Disorder Major Cognitive vulnerability Resting state fMRI medicine.disease Magnetic Resonance Imaging Temporal Lobe 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies Case-Control Studies Endogenous depression Major depressive disorder Female Orbitofrontal cortex Psychology human activities 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders. 198:56-63 |
| ISSN: | 0165-0327 |
| Popis: | Background The hopelessness theory of depression posits that individuals with negative cognitive styles are at risk of developing depression following negative life events. The purpose of this work was to examine whether individuals with cognitive vulnerability to depression (CVD) exhibit similar spontaneous brain activity patterns as compared to patients with major depressive disorder (MDD). Methods Subjects with CVD (N=32), drug-naive first-episode patients with major depressive disorder (N=32), and sex-, age- and education-matched healthy controls (HCs; N=35) were subjected to resting state functional magnetic resonance imaging (RS-fMRI) and amplitudes of low-frequency fluctuation (ALFF) was compared between the groups. Pearson correlation analysis was performed between regional ALFFs and psychometric scores, namely the Cognitive Style Questionnaire (CSQ) and the Center for Epidemiologic Studies Depression (CES-D) scale scores. Results Significant group differences in ALFF values were observed bilaterally in the orbitofrontal cortex (OFC) and insular cortex (IC), and in the left fusiform gyrus (FFG). Compared to HCs, CVD subjects had reduced ALFFs in the bilateral OFC and increased ALFF in the bilateral IC and the left FFG, which were similar to the differences observed between the HCs and MDD patients. Compared to MDD patients, CVD subjects showed significant reduced ALFF values in right IC. Additionally, CSQ scores for the CVD group correlated with ALFF values in the left IC. Limitations We did not conduct a longitudinal study. Our findings were limited in cross-sectional analysis. Conclusions A hypoactive OFC and hyperactive IC in a resting-state may underlie an imbalance in the spontaneous brain activity in orbitofrontal-insular circuits, and these differences may represent a trait-related marker of vulnerability to depression. |
| Databáze: | OpenAIRE |
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