Genetic analysis of MAPT haplotype diversity in frontotemporal dementia
| Autor: | Bernd Ibach, Alexander Kurz, Matthias Riemenschneider, Simon M. Laws, Tamara Eisele, Patricia Friedrich, Jakob Müller, Josef Bäuml, Janine Diehl-Schmid, Hans Förstl |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Aging tau Proteins Biology Genetic analysis Progressive supranuclear palsy Microtubule associated protein tau Germany mental disorders medicine Prevalence Corticobasal degeneration Humans Genetic Predisposition to Disease Genetics General Neuroscience Incidence Haplotype nutritional and metabolic diseases Genetic Variation medicine.disease nervous system diseases Increased risk Haplotypes Dementia Female Neurology (clinical) Geriatrics and Gerontology Developmental Biology Frontotemporal dementia |
| Zdroj: | Neurobiology of aging. 29(8) |
| ISSN: | 1558-1497 |
| Popis: | The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies. |
| Databáze: | OpenAIRE |
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