Three cases of the myelodysplastic syndrome with pericentric inversion of chromosome 16
| Autor: | C. G. Geary, M. J. Lewis, M. N. Narayanan, K. I. Cinkotai, Christine J. Harrison |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Mitosis Biology Gastroenterology Chromosome 16 hemic and lymphatic diseases Internal medicine medicine Eosinophilia Humans Chromosomal inversion Aged Genetics Myelodysplastic syndromes Cytogenetics Karyotype Hematology respiratory system biochemical phenomena metabolism and nutrition Middle Aged medicine.disease Prognosis Karyotyping Myelodysplastic Syndromes Chromosome Inversion Female Good prognosis Myeloid leukaemia medicine.symptom Chromosomes Human Pair 16 Follow-Up Studies |
| Zdroj: | British journal of haematology. 85(1) |
| ISSN: | 0007-1048 |
| Popis: | Inversion of chromosome 16, inv(16)(p13q22), is characteristic of acute myeloid leukaemia (AML) with eosinophilia and is rarely found in the myelodysplastic syndrome (MDS). We report three cases of MDS in which inv(16) was observed. They were classified to FAB subtypes RA, RARS and RAEBT; eosinophilia or abnormal eosinophils were not observed. The disease appeared to be stable in all three patients. MDS with inv(16) without eosinophilia may be a rare subgroup associated with a good prognosis. |
| Databáze: | OpenAIRE |
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