Testing of the World Health Organization-recommended formulations for surgical hand preparation and proposals for increased efficacy

Autor: Manfred Rotter, Michael Kundi, Benedetta Allegranzi, Miranda Suchomel, Didier Pittet
Rok vydání: 2011
Předmět:
Adult
Microbiology (medical)
medicine.medical_specialty
Time Factors
Adolescent
European norm
Chemistry
Pharmaceutical
media_common.quotation_subject
Ethanol/chemistry/pharmacology
Antisepsis
World Health Organization
Preoperative Care/standards
World health
2-Propanol
Young Adult
Hygiene
Hand/microbiology
Preoperative Care
2-Propanol/chemistry/pharmacology
medicine
Humans
Bacteria/drug effects/isolation & purification
Skin
media_common
ddc:616
Bacteria
Ethanol
business.industry
World Health Organization/organization & administration
Volume percent
Antisepsis/methods
Skin/microbiology
General Medicine
Hand
Surgery
Clinical trial
Infectious Diseases
Handwashing/methods/standards
Anesthesia
Practice Guidelines as Topic
Healthcare settings
Anti-Infective Agents
Local
Anti-Infective Agents
Local/chemistry/metabolism/standards
business
Hand Disinfection
Zdroj: Journal of Hospital Infection, Vol. 79, No 2 (2011) pp. 115-8
ISSN: 0195-6701
DOI: 10.1016/j.jhin.2011.05.005
Popis: The 2009 World Health Organization (WHO) Guidelines on hand hygiene in health care recommend alcohol-based hand rubs for both hygienic and pre-surgical hand treatment. Two formulations based on ethanol 80% v/v and 2-propanol 75% v/v are proposed for local preparation in healthcare settings where commercial products are not available or too expensive. Both formulations and our suggested modifications (using mass rather than volume percent concentrations) were evaluated for their conformity with the efficacy requirements of the forthcoming amendment of the European Norm (EN) 12791, i.e. non-inferiority of a product when compared with a reference procedure (1-propanol 60% v/v for 3 min) immediately and 3 h after antisepsis. In this study, the WHO-recommended formulations were tested for 3 min and 5 min. Neither formulation met the efficacy requirements of EN 12791 with 3 min application. Increasing the respective concentrations to 80 w/w (85% v/v) and 75 w/w (80% v/v), together with a prolonged application of 5 min, rendered the immediate effect of both formulations non-inferior to the reference antisepsis procedure. This was not the case with the 3h effect, which remained significantly inferior to the reference. Although the original formulations do not meet the efficacy requirements of EN 12791, the clinical significance of this finding deserves further clinical trials. To comply with the requirement of EN 12791, an amendment to the formulations is possible by increasing the alcohol concentrations through changing volume into mass percent and prolonging the duration of application from 3 min to 5 min.
Databáze: OpenAIRE
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