Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis
| Autor: | Yet-Ran Chen, Chih-Yu Lin, Ning-Sun Yang, Yu-Chen Huang, Pei-Wen Hsiao, Sheng-Yen Lin, Wen-Chi Wei, Wen-Chin Yang, Chun-Wen Lan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Transgene Cellular differentiation Phytochemicals Mice Transgenic Biology Article law.invention Metastasis Mice 03 medical and health sciences 0302 clinical medicine law Cell Line Tumor Granulocyte Colony-Stimulating Factor medicine Animals Humans Bidens Neoplasm Metastasis Multidisciplinary Myeloid-Derived Suppressor Cells Polyynes Cell Differentiation medicine.disease 030104 developmental biology medicine.anatomical_structure Cell culture 030220 oncology & carcinogenesis Immunology Cancer research Heterografts Suppressor Bone marrow Signal transduction Function (biology) |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep36663 |
| Popis: | Myeloid-derived suppressor cells (MDSCs) are implicated in the promotion of tumor metastasis by protecting metastatic cancerous cells from immune surveillance and have thus been suggested as novel targets for cancer therapy. We demonstrate here that oral feeding with polyacetylenic glycosides (BP-E-F1) from the medicinal plant Bidens pilosa effectively suppresses tumor metastasis and inhibits tumor-induced accumulation of granulocytic (g) MDSCs, but does not result in body weight loss in a mouse mammary tumor-resection model. BP-E-F1 is further demonstrated to exert its anti-metastasis activity through inhibiting the differentiation and function of gMDSCs. Pharmacokinetic and mechanistic studies reveal that BP-E-F1 suppresses the differentiation of gMDSCs via the inhibition of a tumor-derived, G-CSF-induced signaling pathway in bone marrow cells of test mice. Taken together, our findings suggest that specific plant polyacetylenic glycosides that target gMDSC differentiation by communicating with bone marrow cells may hence be seriously considered for potential application as botanical drugs against metastatic cancers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|