Serum cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, klotho and fibroblast growth factor-23 in the early prediction of acute kidney injury associated with sepsis in a Chinese emergency cohort study
Autor: | Xiaolu Ma, Yuanyuan Pei, Ji-Hong Zhu, Fang'e Shi, Guangping Zhou, Pengfei Wang |
---|---|
Rok vydání: | 2021 |
Předmět: |
Fibroblast growth factor 23
Male medicine.medical_specialty China Enzyme-Linked Immunosorbent Assay urologic and male genital diseases Sepsis Lipocalin-2 Serum cystatin Predictive Value of Tests Internal medicine Early prediction medicine Humans Hepatitis A Virus Cellular Receptor 1 Prospective Studies Cystatin C Klotho Klotho Proteins Aged urogenital system business.industry Acute kidney injury General Medicine Acute Kidney Injury medicine.disease female genital diseases and pregnancy complications Neutrophil gelatinase-associated lipocalin Fibroblast Growth Factor-23 Endocrinology Early Diagnosis Female business Biomarkers Cohort study |
Zdroj: | European journal of medical research. 27(1) |
ISSN: | 2047-783X |
Popis: | Background Acute kidney injury (AKI) is a common and critical complication of sepsis, and is associated with unacceptable morbidity and mortality. Current diagnostic criteria for AKI was insensitive for early detection. Novel biomarkers including cystatin C, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), klotho and fibroblast growth factor-23 (FGF-23) can predict AKI earlier and allow immediate interventions. We aimed to determine the diagnostic performance of these biomarkers for detecting AKI in sepsis patients. Methods This prospective observational study was conducted between May 2018 and November 2020, enrolling 162 sepsis patients eventually. The AKI was defined in accordance with 2012 KDIGO criteria and we divided patients into non-AKI (n = 102) and AKI (n = 60) groups. Serum levels of several AKI biomarkers were detected by ELISA. The relationship between biomarker levels on admission of AKI was analyzed and discrimination performances comparison were performed. Results AKI incidence was up to 37.0% (60/162) during hospitalization. Compared with non-AKI group, both serum cystatin C, KIM-1, NGAL and FGF-23 were significantly elevated at admission in septic AKI patients. The areas under the receiver operating curves demonstrated that serum cystatin C had modest discriminative powers for predicting AKI after sepsis, and cystatin C combined with serum creatinine in the prediction of septic AKI increased the diagnostic sensitivity prominently. Conclusion Serum cystatin C, KIM-1, NGAL and FGF-23 levels were both increased in septic AKI patients. Our study provided reliable evidence that cystatin C solely and combined with serum creatinine may accurately and sensitively predict septic AKI of patients on admission. |
Databáze: | OpenAIRE |
Externí odkaz: |