Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis
| Autor: | Young Ho Lee, Stephen M. Hewitt, Seok Hyung Lee, Soo-Heang Eo, Junya Fukuoka, Jun Hanaoka, Shuhei Inoue, Tae Woo Kim, Chel Hun Choi, Kyung Hee Noh, Joon-Yong Chung, HyungJun Cho, Haruhisa Kitano |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Male Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor B Lung Neoplasms SCP3 Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor D lcsh:Medicine Cell Cycle Proteins Metastasis chemistry.chemical_compound 0302 clinical medicine Non-small cell lung cancer Carcinoma Non-Small-Cell Lung Medicine Lymphangiogenesis Lymph node Nuclear Proteins General Medicine Middle Aged Prognosis Vascular endothelial growth factor B Vascular endothelial growth factor DNA-Binding Proteins medicine.anatomical_structure Vascular endothelial growth factor C 030220 oncology & carcinogenesis Lymphatic Metastasis Female medicine.medical_specialty Synaptonemal complex protein 3 General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Internal medicine Cell Line Tumor Humans Lung cancer Aged Lymph node metastasis business.industry Research lcsh:R medicine.disease Survival Analysis 030104 developmental biology chemistry Multivariate Analysis business |
| Zdroj: | Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-10 (2017) Journal of Translational Medicine |
| ISSN: | 1479-5876 |
| DOI: | 10.1186/s12967-017-1241-5 |
| Popis: | Background The interaction of vascular endothelial growth factor-C (VEGF-C)/VEGF-D/VEGF receptor-3 is considered to be a major driver of lymphangiogenesis, however the mechanism of this process remains unclear. We aimed to investigate the possible lymphangiogenic significance of synaptonemal complex protein 3 (SCP3) in non-small cell lung cancer (NSCLC). Methods The expression of SCP3, VEGF-C, and VEGF-D were measured and examined a correlation between SCP3 and VEGF-C or VEGF-D in various human lung cancer cell lines. Subsequently, we assessed SCP3, VEGF-A, VEGF-B, VEGF-C, and VEGF-D expression in archival tumor tissues from 89 NSCLC patients with lymph node (LN) metastasis by combined immunohistochemistry with quantitative digital image analysis. Results Positive correlations between SCP3 and VEGF-C expression (R 2 = 0.743) and VEGF-D expression (R 2 = 0.932) were detected in various human lung cancer cell lines. The high expression of SCP3, VEGF-A, VEGF-B, VEGF-C, and VEGF-D were detected in 24 (27.0%), 22 (24.7%), 27 (30.3%), 27 (30.3%), and 24 cases (27.0%), respectively. Notably, SCP3 positively correlated with VEGF-C and VEGF-D expression (for both, P |
| Databáze: | OpenAIRE |
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