Safety of sperm washing and ART outcome in 741 HIV-1-serodiscordant couples
| Autor: | Enrico Ferrazzi, C. Lanzani, Bina Parrilla, M. Oneta, Valeria Savasi, T. Persico |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Pregnancy Rate Reproductive Techniques Assisted medicine.medical_treatment media_common.quotation_subject Semen Fertility Fertilization in Vitro Insemination Specimen Handling Pregnancy HIV Seropositivity medicine Humans Sperm Injections Intracytoplasmic Insemination Artificial Homologous media_common Gynecology Acquired Immunodeficiency Syndrome urogenital system business.industry Artificial insemination Rehabilitation Sperm washing Obstetrics and Gynecology Viral Load medicine.disease Spermatozoa Tissue Donors Pregnancy rate Treatment Outcome Reproductive Medicine Serodiscordant Female business |
| Zdroj: | Human Reproduction. 22:772-777 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/del422 |
| Popis: | BACKGROUND: To evaluate the safety of sperm washing and assisted reproduction technique (ART) outcome offered to serodiscordant couples with a human immunodeficiency virus-1 (HIV-1)-positive male. METHODS: Sperm washing was performed and checked by RT-PCR on each semen sample before its fresh usage. Intrauterine insemination (IUI) or IFV/ICSI was offered according to fertility profile of each couple. Non-infected women underwent HIV testing 2 weeks before each procedure and for up to 6 months after. RESULTS: Seven hundred and forty-one couples entered the study of a possible 2011 serodiscordant couples counselled over 4 years. Superovulation and IUI were performed in 581 couples, where the pregnancy rate per cycle and pregnancy rate per couple were 19 and 78%, respectively, with multiple pregnancy rate being 4%. One hundred and sixty couples were treated by IVF/ICSI, where pregnancy rate per cycle and per couple were 22 and 41%, respectively, with multiple pregnancy rate being 10%. All female partners were still HIV-1 negative at follow-up. CONCLUSION: Sperm washing within a programme of reproductive counselling was proved to be safe in this large series of serodiscordant couples. The overall pregnancy rate (70.3%), independent of the procedure used (IUI or IVF/ICSI), justifies the effort of the medical team in setting up and implementing dedicated centres and of the individual patient in seeking a safe pregnancy. |
| Databáze: | OpenAIRE |
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