Carotid Plaques Correlates in Patients With Familial Hypercholesterolemia
| Autor: | M. T. Malecki, M. Kloch-Badelek, Małgorzata Waluś-Miarka, M. Wojcik, Danuta Czarnecka, B. Idzior-Waluś, J. Starzyk, Wiktoria Wojciechowska, Marek Sanak, Maria Kapusta |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Apolipoprotein B Diastole Blood Pressure Familial hypercholesterolemia 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Hyperlipoproteinemia Type II 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Risk Factors Internal medicine medicine Humans cardiovascular diseases 030212 general & internal medicine Aged Apolipoproteins B Creatinine biology business.industry Cholesterol HDL nutritional and metabolic diseases Odds ratio Middle Aged medicine.disease Atherosclerosis Blood pressure chemistry cardiovascular system Cardiology biology.protein lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine business Lipoproteins HDL Body mass index |
| Zdroj: | Angiology. 67(5) |
| ISSN: | 1940-1574 |
| Popis: | Patients with familial hypercholesterolemia (FH) are at increased risk of premature cardiovascular disease. We compared factors associated with the presence of carotid plaques and carotid intima–media thickness (cIMT), markers of subclinical atherosclerosis, in 241 patients with FH (98, 40.7% men; mean age 41 ± 18.4 years). Patients with FH having carotid plaques (36.5%) had mean age, apolipoprotein (apo) B, glucose, apoA1, systolic blood pressure (SBP) and diastolic BP, waist/hip ratio (WHR), and body mass index higher than patients without plaques. Logistic regression revealed that apoB (odds ratio [OR] per 1 unit change 1.03, P = .005), high-density lipoprotein cholesterol (HDL-C; OR per 1 standard deviation [SD] change 0.59, P = .015), and non-HDL-C (OR per 1SD change 1.53, P = .04) were significantly associated with the presence of plaques. The cIMT correlated with obesity parameters, BP, apoB, glucose, high-sensitivity C-reactive protein, creatinine, γ-glutamyl transpeptidase, and alanine transaminase ( P < .001). Regression analysis revealed that cIMT was significantly associated with apoB, SBP, and WHR. These results confirm the role of apoB-containing lipoproteins and low HDL-C with the presence of carotid plaques and apoB, BP, and WHR with cIMT. |
| Databáze: | OpenAIRE |
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