Evidence of a key-role for histamine from mast cells in the analgesic effect of clomipramine in rats
| Autor: | Santina Chiechio, R. Arrigo-Reina |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Clomipramine medicine.medical_specialty Allergy Injections Subcutaneous medicine.medical_treatment Immunology Pharmacology Histamine Release Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals p-Methoxy-N-methylphenethylamine Mast Cells Enzyme Inhibitors Saline Analgesics business.industry Methylhistidines Mast cell medicine.disease Rats medicine.anatomical_structure Nociception Endocrinology chemistry Toxicity Analysis of variance Analgesia business Injections Intraperitoneal Selective Serotonin Reuptake Inhibitors Histamine medicine.drug |
| Zdroj: | Inflammation Research. 47:44-48 |
| ISSN: | 1420-908X 1023-3830 |
| DOI: | 10.1007/s000110050262 |
| Popis: | Objective and Design: We investigated the role of neuronal and mast cell histamine in the analgesic effect of clomipramine.¶Subjects: Male Sprague-Dawley rats (4–6 weeks old) were used (n = 228).¶Treatment: Clomipramine (10, 20 or 40 mg/kg ip) was injected in rats pretreated with [a] saline icv or ip, [b] α-fluoromethylhistidine (α-FMH, 200 μg icv), [c] compound 48/80 (C48/80, 1 mg/kg ip). Other rats were pretreated with clomipramine, before C48/80.¶Methods: Antinociceptive responses were determined before and 30, 60, 90, 120 min after drug injection by tail-flick (TFT) and hot-plate (HPT) tests. Results for each treatment group are given as mean %MPE ± SEM (Student's t-test, ANOVA).¶Results: Clomipramine produced no significant changes in TFT and HPT in saline- or α-FMH-pretreated rats. Following C48/80, clomipramine (10 and 20 mg/kg) produced a dose-related significant increase in latencies, between 30 and 120 min: 28.5 ± 5.7 vs 8 ± 1.6 (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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