Prednisolone treatment of respiratory syncytial virus infection: a randomized controlled trial of 147 infants
| Autor: | Lise L. Thomsen, Jens-Christian Holm, Birgitte Friis, Jens Erik Nielsen, E. Levin, Marta Nir, Susanne M. Bülow, Hans Erik Nielsen, Tina Møller, Mie E. Bonde-Hansen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty medicine.drug_class Prednisolone Respiratory Syncytial Virus Infections law.invention Pharmacotherapy Randomized controlled trial Double-Blind Method law medicine Humans Prospective cohort study Glucocorticoids Asthma Inhalation business.industry Infant Length of Stay medicine.disease Clinical trial Logistic Models Treatment Outcome Pediatrics Perinatology and Child Health Corticosteroid Drug Therapy Combination Female business medicine.drug Follow-Up Studies |
| Zdroj: | Pediatrics. 104(6) |
| ISSN: | 1098-4275 |
| Popis: | Objective. To evaluate the effect of systemic prednisolone as an adjunct to conventional treatment with β2-agonist, respiratory support, and fluid replacement in hospitalized infants Methods. The study was randomized, double-blind, and placebo-controlled. During the winter of 1995–1996, 147 infants Main Outcome Measures. The acute effect variables were duration of stay in hospital, use of medicine, and supportive measures while in hospital. At follow-up 1 month after discharge, the acute effect variables were duration of illness, start in day care center, morbidity, and use of medicine. At follow-up 1 year after discharge, the acute effect variables were morbidity, use of medicine, and skin prick tests with allergens. Results. Prednisolone treatment had no effect on any of the outcome measures. Conclusions. Our randomized prospective study in infants hospitalized with acute RSV infection showed no effect of systemic prednisolone treatment either in the acute state of RSV infection, nor in the follow-up 1 month and 1 year after admission to hospital. We find our results in agreement with the largest studies reported earlier; therefore, corticosteroid, whether by the systemic route or by inhalation, should not be prescribed to infants with RSV infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|