Kinase activity in the olfactory bulb is required for odor memory consolidation
| Autor: | Thomas A. Cleland, Tae-Young P. Kim, Michelle T. Tong |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male animal structures Memory Long-Term Cognitive Neuroscience Carbazoles Hippocampus Tropomyosin receptor kinase B Biology Indole Alkaloids 03 medical and health sciences Cellular and Molecular Neuroscience Mice 0302 clinical medicine Discrimination Psychological Ca2+/calmodulin-dependent protein kinase Animals Kinase activity Enzyme Inhibitors Memory Consolidation Research Receptor Protein-Tyrosine Kinases Olfactory Perception Olfactory Bulb Associative learning Olfactory bulb Smell 030104 developmental biology Neuropsychology and Physiological Psychology Odor nervous system Odorants Memory consolidation Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Learningmemory (Cold Spring Harbor, N.Y.). 25(5) |
| ISSN: | 1549-5485 |
| Popis: | Long-term fear memory formation in the hippocampus and neocortex depends upon brain-derived neurotrophic factor (BDNF) signaling after acquisition. Incremental, appetitive odor discrimination learning is thought to depend substantially on the differentiation of adult-born neurons within the olfactory bulb (OB)—a process that is closely associated with BDNF signaling. We sought to elucidate the role of neurotrophin signaling within the OB on odor memory consolidation. Male mice were trained on odor–reward associative discriminations after bilateral infusion of the kinase inhibitor K252a, or vehicle control, into the OB. K252a is a partially selective inhibitor of tyrosine kinase (Trk) receptors, including the TrkB receptor for BDNF, though it also inhibits other plasticity-related kinases such as PKC and CaMKII/IV. K252a infusion into the OB did not impair odor acquisition or short-term (2 h) memory for the learned discriminations, but significantly impaired long-term (48 h) odor memory (LTM). This LTM deficit also was associated with reduced selectivity for the conditioned odorant in a reward-seeking digging task. Infusions of K252a immediately prior to testing did not impair LTM recall. These results indicate that kinase activation in the OB is required for the consolidation of odor memory of incrementally acquired information. |
| Databáze: | OpenAIRE |
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