Rhes Is Involved in Striatal Function
| Autor: | Daniela Terracciano, Maria Teresa Pirro, Claudio Arra, Antonio Riccio, Roberto Di Lauro, Daniela Spano, Annamaria Rosica, Vincenzo Macchia, Juan Bernal, Andrea Affuso, Pratibha Mithbaokar, Patrizia Campolongo, Igor Branchi, Enrico Alleva |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Anxiety Biology Mice 03 medical and health sciences Sex Factors 0302 clinical medicine GTP-binding protein regulators GTP-Binding Proteins Internal medicine Mammalian Genetic Models with Minimal or Complex Phenotypes medicine Animals RNA Messenger Molecular Biology Gene 030304 developmental biology Brain Chemistry Mice Knockout 0303 health sciences Body Weight Thyroid Age Factors Gene Expression Regulation Developmental Cell Biology Embryo Mammalian Embryonic stem cell Null allele Corpus Striatum 3. Good health Motor coordination Motor Skills Disorders Endocrinology medicine.anatomical_structure Female 030217 neurology & neurosurgery Hormone |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1098-5549 |
| DOI: | 10.1128/mcb.24.13.5788-5796.2004 |
| Popis: | 9 pages, 10 figures.-- et al. The development and the function of central nervous system depend on thyroid hormones. In humans, the lack of thyroid hormones causes cretinism, a syndrome of severe mental deficiency. It is assumed that thyroid hormones affect the normal development and function of the brain by activating or suppressing target gene expression because several genes expressed in the brain have been shown to be under thyroid hormone control. Among these, the Rhes gene, encoding a small GTP-binding protein, is predominantly expressed in the striatal region of the brain. To clarify the role of Rhes in vivo, we disrupted the Rhes gene by homologous recombination in embryonic stem cells and generated mice homozygous for the Rhes null mutation (Rhes(-/-)). Rhes(-/-) mice were viable but weighed less than wild-type mice. Furthermore, they showed behavioral abnormalities, displaying a gender-dependent increase in anxiety levels and a clear motor coordination deficit but no learning or memory impairment. These results suggest that Rhes disruption affects selected behavioral competencies. This work was supported in part by Telethon grant GP0208Y01, by a grant from the Associazione Italiana per la Ricerca sul Cancro (to R.D.L.), by Ministero dell'Università e della Ricerca Scientifica e Tecnologica grant “I geni dell'uomo” cluster 01, and by Italian Ministry of Health project ALZ1 (to E.A.). A.R., M.T.P., P.M., and A.A. were supported by Biogem s.c.a.r.l., Italy. |
| Databáze: | OpenAIRE |
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