Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility
| Autor: | Atilla Halil Elhan, Neslihan Aygun Kocabas, Semra Sardas, Ali Esat Karakaya, S. Cholerton, Ann K. Daly |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Genotype Turkey CYP1B1 Clinical Biochemistry Breast Neoplasms Biology Biochemistry Superoxide dismutase Breast cancer Gene Frequency Internal medicine Odds Ratio medicine Humans Genetic Predisposition to Disease Allele frequency Alleles chemistry.chemical_classification Reactive oxygen species Polymorphism Genetic Superoxide Dismutase fungi Case-control study Genetic Variation DNA Cell Biology General Medicine medicine.disease Endocrinology chemistry Case-Control Studies Immunology biology.protein Population study Female |
| Zdroj: | Cell Biochemistry and Function. 23:73-76 |
| ISSN: | 1099-0844 0263-6484 |
| DOI: | 10.1002/cbf.1128 |
| Popis: | Within mitochondria, manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species (ROS). An alanine-9valine (Ala-9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer. Our present case-control study was performed to explore the association between MnSOD genetic polymorphism and individual susceptibility to breast cancer. Ala-9Val polymorphism in the signal sequence of the protein for MnSOD was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a study population. There was no significant difference in risk for breast cancer development between patients positive and negative for the MnSOD Ala allele with adjusted odds ratio (OR): 0.86 (95% confidence interval (CI) 0.43 to 1.72). When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferase COMT-L (V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index (BMI) greater than 24 kg m(-2) (OR: 1.42 (95%CI = 1.04-1.93)). Copyright (C) 2004 John Wiley Sons, Ltd. |
| Databáze: | OpenAIRE |
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