Effects of Human and Ovine Pancreatic Secretory Trypsin Inhibitors on the Proliferation of Normal Human Fibroblasts
| Autor: | Reynolds Gw, Hamilton I, Tse Ca, Scott Gk, Sharfe N |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Alpha (ethology)
Stimulation Biochemistry Epidermal growth factor medicine Animals Humans Drug Interactions Fibroblast Pancreatic Secretory Trypsin Inhibitor Sheep Dose-Response Relationship Drug Epidermal Growth Factor DNA synthesis Cell growth Chemistry DNA Fibroblasts Trypsin Molecular biology medicine.anatomical_structure Trypsin Inhibitor Kazal Pancreatic alpha 1-Antitrypsin Mitogens Trypsin Inhibitors Cell Division medicine.drug |
| Zdroj: | Biological Chemistry Hoppe-Seyler. 371:79-84 |
| ISSN: | 0177-3593 |
| Popis: | Human pancreatic secretory trypsin inhibitor inhibited cell-surface proteolytic activity in human fibroblasts. In the range of concentrations which caused proteinase inhibition, fibroblast proliferation was also inhibited by this reagent and by the ovine equivalent. At lower concentrations, there was some evidence for a mitogenic effect, and this was confirmed by obvious stimulation of DNA synthesis at these concentrations. Human alpha 1-proteinase inhibitor, previously demonstrated to be an inhibitor of fibroblast proliferation, was also mitogenic at concentrations lower than those which inhibited proteolytic activity and cell proliferation. Human pancreatic secretory trypsin inhibitor and epidermal growth factor apparently work through independent mechanisms, since their mitogenic effects are additive. |
| Databáze: | OpenAIRE |
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