Decreased Serum Levels of S-100B Protein Reflect Successful Treatment Effects in a Rabbit Model of Acute Ischemic Stroke
| Autor: | Sean D. Woods, Paula K. Roberson, John D. Lowery, Rene Flores, William C. Culp, Robert D. Skinner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Urology 030226 pharmacology & pharmacy Tissue plasminogen activator Article 03 medical and health sciences 0302 clinical medicine medicine.artery medicine Embolization Stroke Acute ischemic stroke medicine.diagnostic_test business.industry animal model biomarkers medicine.disease Transcranial Doppler S-100B Psychiatry and Mental health Neurology Angiography Microbubbles Neurology (clinical) Internal carotid artery business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Open Neurology Journal |
| ISSN: | 1874-205X |
| Popis: | Serum levels of S-100B were investigated as a marker for infarct volume and response to treatment following acute ischemic stroke in rabbits. Following subselective angiography, rabbits (n=31) were embolized by injection of a 3-day-old blood clot (0.6x4.0-mm) into the internal carotid artery. Treatment began 1-hr post-embolization, groups included: Control (n=8, embolization only), tissue plasminogen activator (tPA, n=12, 0.9mg/kg), and perflutren lipid microbubbles with transcranial ultrasound (MB+US, n=11, MB at 0.16mg/kg, US at 1-MHz pulsed-wave, 0.8 W/cm(2) for 1-hr). Serum S-100B levels were significantly increased (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|