l-Methamphetamine and selective MAO inhibitors decrease morphine-reinforced and non-reinforced behavior in rats; Insights towards selegiline's mechanism of action
| Autor: | Shuangteng He, Kenneth Grasing |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Clorgyline Monoamine Oxidase Inhibitors Clinical Biochemistry Self Administration Pharmacology Toxicology Biochemistry Extinction Psychological Methamphetamine Behavioral Neuroscience chemistry.chemical_compound Selegiline medicine Animals Clorgiline Rats Wistar Biological Psychiatry Rasagiline Behavior Animal Morphine Body Weight Rats Substance Withdrawal Syndrome chemistry Indans Conditioning Operant Central Nervous System Stimulants Monoamine oxidase B Self-administration Psychology Morphine Dependence Reinforcement Psychology medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 85:675-688 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2006.10.022 |
| Popis: | Selegiline is an inhibitor of type B monoamine oxidase (MAO) with psychostimulant effects that can decrease morphine-reinforced and non-reinforced responding. The present study was undertaken to compare the effects of MAO inhibition and treatment with L-methamphetamine, the major psychostimulant metabolite of selegiline, on these behaviors. After rats acquired a stable pattern of morphine self-administration under a progressive ratio schedule, chronic treatment was initiated with vehicle, L-methamphetamine, clorgyline (a selective inhibitor of MAO-A), or rasagiline (a selective inhibitor of MAO-B); with both MAO inhibitors administered at a dose selective for one MAO isoform and a higher dose that inhibited both isoforms. Rats were evaluated for up to four cycles of opiate dependence maintained by morphine self-administration and withdrawal during which extinction responding was recorded. Most behavioral measures (92.4%) did not differ in animals evaluated during an initial and subsequent cycles of dependence and withdrawal. All active treatments attenuated non-reinforced responding during extinction. Morphine reinforcement was also decreased by each of the three active treatments, but greater and more prolonged effects were observed following inhibition of MAO-B with rasagiline. Responding during either cue- or morphine-induced reinstatement was attenuated by either clorgyline or rasagiline administered at nonselective doses, but not by either compound administered at selective dose levels. Treatment with L-methamphetamine did not produce significant effects on cue-induced reinstatement, but decreased non-reinforced responding during morphine-induced reinstatement. These findings indicate that morphine reinforcement and different non-reinforced behaviors differ greatly in their susceptibility to modification by psychostimulant treatment or MAO inhibition. |
| Databáze: | OpenAIRE |
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