Sources of Disseminated Mycobacterium avium Infection in AIDS
| Autor: | Susan Tvaroha, Richard Waddell, A D Lein, Robert D. Arbeit, Matthew H. Samore, Lisa R. Hirschhorn, M R Grove, C. F. von Reyn, Anna N. A. Tosteson, J Lumio, C. R. Horsburgh, Matti Ristola |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Opportunistic infection AIDS-Related Opportunistic Infections Mycobacterium Avium Infection Mycobacterium avium-intracellulare infection Biology Endoscopy Gastrointestinal Cohort Studies Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine medicine Humans Prospective Studies Mycobacterium avium-intracellulare Infection Proportional Hazards Models Acquired Immunodeficiency Syndrome Hazard ratio Mycobacterium avium Complex medicine.disease Pneumocystis Infections Infectious Diseases Seafood Immunology Food Microbiology Female Water Microbiology Cohort study |
| Zdroj: | Journal of Infection. 44:166-170 |
| ISSN: | 0163-4453 |
| DOI: | 10.1053/jinf.2001.0950 |
| Popis: | To identify the sources of disseminated Mycobacterium avium complex (MAC) infection in AIDS.HIV positive subjects with CD4 counts100/mm(3) in Atlanta, Boston, New Hampshire and Finland were entered in a prospective cohort study. Subjects were interviewed about potential MAC exposures, had phlebotomy performed for determination of antibody to mycobacterial lipoarabinomannin and for culture. Patient-directed water samples were collected from places of residence, work and recreation. Patients were followed for the development of disseminated MAC. Univariate and multivariate risk factors for MAC were analyzed.Disseminated MAC was identified in 31 (9%) subjects. Significant risks in univariate analysis included prior Pneumocystis carinii pneumonia (PCP) (hazard ratio 1.821), consumption of spring water (4.909), consumption of raw seafood (34.3), gastrointestinal endoscopy (2.894), and showering outside the home (0.388). PCP, showering and endoscopy remained significant in a Cox proportional hazards model. There was no association between M. avium colonization of home water and risk of MAC. In patients with CD425, median OD antibody levels to lipoarabinomannin at baseline were 0.054 among patients who did not develop MAC and 0.021 among patients who did develop MAC (P=0.077).MAC infection results from diverse and likely undetectable environmental and nosocomial exposures. Mycobacterial infection before HIV infection may confer protection against disseminated MAC in advanced AIDS. |
| Databáze: | OpenAIRE |
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