Opiate receptor avidity is reduced in non-motor impaired MPTP-lesioned rhesus monkeys
| Autor: | Thomas G. Aigner, Robert M. Cohen, Doris J. Doudet, Richard E. Carson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Narcotic Antagonists Dopamine Agents In Vitro Techniques chemistry.chemical_compound Reference Values Opioid receptor Dopamine Internal medicine medicine Animals Tissue Distribution Avidity Fluorodopa Neurotransmitter Molecular Biology Chemistry General Neuroscience MPTP Putamen Brain Receptor antagonist Macaca mulatta Naltrexone Endocrinology nervous system 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Receptors Opioid Neurology (clinical) Tomography Emission-Computed Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 806:292-296 |
| ISSN: | 0006-8993 |
| Popis: | Opiate receptor avidity, roughly equivalent to the ratio of unoccupied receptor density to the receptor dissociation constant (B′max/KD), was measured in four MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-lesioned rhesus monkeys and nine normal controls with positron emission tomography (PET) and 6-deoxy-6-β-[ 18 F ]fluoronaltrexone (cyclofoxy, CF), a μ- and κ-opiate receptor antagonist. Although the MPTP-lesioned monkeys were dopamine deficient as measured with [ 18 F ]- l -fluorodopa ([ 18 F ]-DOPA) and PET [Doudet et al., 6-[ 18 F ]- l -DOPA imaging of the dopamine neostriatal system in normal and clinically normal-MPTP-treated rhesus monkeys, Exp. Brain Res. 78 (1989) 69–80], they had clinically recovered from the acute motor effects of MPTP exposure. Opiate receptor avidity was found to be reduced by 30–35% in the opiate-receptor rich areas of caudate, anterior putamen, thalamus, and amygdala of the MPTP-lesioned animals. The results suggest that opiate pathways make a significant contribution to the adjustment of cortico–striatal–thalamic pathway activity and thereby to behavior in rhesus monkeys following dopamine loss. |
| Databáze: | OpenAIRE |
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