Chemical delivery array with millisecond neurotransmitter release
| Autor: | Magnus Berggren, Theresia Arbring Sjöström, Amanda Jonsson, Daniel Simon, Klas Tybrandt |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Time Factors
Computer science Atom and Molecular Physics and Optics Other Engineering and Technologies not elsewhere specified Nanotechnology Signalbehandling 02 engineering and technology 010402 general chemistry 01 natural sciences neurotransmitters Datorteknik Electrophoresis Microchip chemistry.chemical_compound Drug Delivery Systems Biomedicinsk laboratorievetenskap/teknologi Chemical specificity Animals Humans Övrig annan teknik Biomedical Laboratory Science/Technology Computer Engineering Neurotransmitter Research Articles Millisecond Neurotransmitter Agents Multidisciplinary Neural Prosthesis Organic electronics SciAdv r-articles 021001 nanoscience & nanotechnology iontronics 0104 chemical sciences Synaptic function chemistry Applied Sciences and Engineering Temporal resolution electrophoresis Delivery point Drug delivery drug delivery Signal Processing Atom- och molekylfysik och optik 0210 nano-technology Research Article |
| Zdroj: | Science Advances |
| Popis: | Addressable organic electronic neurotransmitter delivery array with switching ~50 ms, approaching synaptic signaling speed. Technologies that restore or augment dysfunctional neural signaling represent a promising route to deeper understanding and new therapies for neurological disorders. Because of the chemical specificity and subsecond signaling of the nervous system, these technologies should be able to release specific neurotransmitters at specific locations with millisecond resolution. We have previously demonstrated an organic electronic lateral electrophoresis technology capable of precise delivery of charged compounds, such as neurotransmitters. However, this technology, the organic electronic ion pump, has been limited to a single delivery point, or several simultaneously addressed outlets, with switch-on speeds of seconds. We report on a vertical neurotransmitter delivery device, configured as an array with individually controlled delivery points and a temporal resolution of 50 ms. This is achieved by supplementing lateral electrophoresis with a control electrode and an ion diode at each delivery point to allow addressing and limit leakage. By delivering local pulses of neurotransmitters with spatiotemporal dynamics approaching synaptic function, the high-speed delivery array promises unprecedented access to neural signaling and a path toward biochemically regulated neural prostheses. |
| Databáze: | OpenAIRE |
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