Serum S100A12 and 30-day mortality after acute intracerebral hemorrhage
| Autor: | Jing Qian, Su-Rong He, Bei-Bei Li, Song-Quan Qian, Xu-Dong Zheng |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Time Factors Clinical Biochemistry Biochemistry Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Hematoma Internal medicine White blood cell medicine Humans cardiovascular diseases Prospective Studies Prospective cohort study Stroke Survival analysis Aged Cerebral Hemorrhage Intracerebral hemorrhage business.industry Biochemistry (medical) S100A12 Protein General Medicine Middle Aged medicine.disease Survival Analysis 030104 developmental biology medicine.anatomical_structure ROC Curve Acute Disease Biomarker (medicine) Female business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 477 |
| ISSN: | 1873-3492 |
| Popis: | Background S100A12 is implicated in inflammatory reactions. The purpose of this study was to determine the association between serum S100A12 concentrations and 30-day mortality in patients with acute intracerebral hemorrhage (ICH). Methods We prospectively included 182 healthy controls and 182 ICH patients within 24 h after stroke onset. Serum samples were collected for the measurement of S100A12 concentrations. Multivariable analysis was used to evaluate the relationship between serum S100A12 concentrations and mortality of ICH patients within 30 days. Results Serum S100A12 concentrations were significantly increased compared to control subjects. S100A12 concentrations were positively correlated with National Institutes of Health Stroke Scale (NIHSS) score, ICH volume, blood glucose concentrations, blood white blood cell count and plasma C-reactive protein concentrations. 36 (19.8%) patients were deceased within 30 days after stroke onset. Non-survivors had significantly higher concentrations of serum S100A12 than survivors. Additionally, Serum S100A12 concentrations significantly discriminated patients at risk of 30-day mortality and its predictive value was equivalent to those of NIHSS score and hematoma volume. Moreover, higher serum S100A12 concentrations showed a significantly higher risk for 30-day mortality and overall survival. Conclusions Higher S100A12 concentrations are positively associated with inflammation, hemorrhagic severity and short-term mortality among ICH patients, indicating S100A12 may represent a biomarker for predicting poor outcome after hemorrhagic stroke. |
| Databáze: | OpenAIRE |
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